Subscribe: Get our latest recipes delivered to your inbox

Close this search box.

Leftover Thanksgiving Turkey and Butternut Squash Enchiladas

This post may contain affiliate links. Please read my disclosure policy.


Put those Thanksgiving leftovers to creative use! Make these Leftover Thanksgiving Turkey and Butternut Squash Enchiladas!These leftover Thanksgiving turkey and butternut squash enchiladas are a great way to put that extra turkey and butternut squash to use!

The addictive filling is made up of a combination of leftover shredded turkey, roasted butternut squash, an abundance of cheeses, savory spices and a creamy green enchilada sauce. After this filling is rolled up in perfectly soft flour tortillas, they sit on a bed of red enchilada sauce and are topped with more cheese. After these butternut squash enchiladas bake until gooey and melty, they are the perfect comforting weeknight meal to satisfy just about anyone’s palette!

Happy Sunday, friends! Is everyone getting super excited for Thanksgiving?! I know I am. I will be traveling back east to spend the holiday with family, which is always a good time. I’m looking forward to the traditional dishes my mom makes every year: sausage stuffing, creamy mashed potatoes, and the most addicting gravy in the world. While I love all things Thanksgiving-related, I almost get more excited for the leftovers. There are so many great ways to put those Thanksgiving leftovers to use, and these turkey and butternut squash enchiladas are just one of the many recipes to make the weekend after the holiday!

Put those Thanksgiving leftovers to creative use! Make these Leftover Thanksgiving Turkey and Butternut Squash Enchiladas!

We love enchiladas. Zach and I make probably make them about two or three times a month. Enchiladas are so great because they are simple, quick, and so utterly comforting. The flour tortillas are the perfect little vessels to wrap up all of that addicting filling. Whether it’s a traditional enchilada filling, or a filling similar to this one, one thing is certain…they are a great weeknight meal.

I hope you guys find these turkey and butternut squash enchiladas as amazing as we do! They are great to make all year round…just substitute that turkey for rotisserie chicken and you’re golden!

Pair these enchiladas with a pale ale. It will really highlight the spice from the chili powder! Have a great week everyone and I’ll talk to you all tomorrow!

Put those Thanksgiving leftovers to creative use! Make these Leftover Thanksgiving Turkey and Butternut Squash Enchiladas!

Enter below for a chance to win some Mission Foods flour tortillas to make your turkey and butternut squash enchiladas! To learn more about Mission Foods, enter to win gift cards and other fun prizes check out their consumer program!

Put those Thanksgiving leftovers to creative use! Make these Leftover Thanksgiving Turkey and Butternut Squash Enchiladas!

Leftover Thanksgiving Turkey and Butternut Squash Enchiladas



Nutritional information is only an estimate. The accuracy of the nutritional information for any recipe on this site is not guaranteed.

Prep Time 15 minutes
Cook Time 1 hour 20 minutes
Total Time 1 hour 35 minutes


  • 1 small butternut squash skinned, seeded and cut into 1/2 inch cubes
  • 3 tablespoons olive oil divided
  • salt and black pepper
  • 1 small onion finely diced
  • 1 4- ounce can diced green chilies
  • 1 1/2 teaspoons chili powder
  • 1 teaspoon cumin
  • 1/2 teaspoon garlic powder
  • 1 10- ounce can green enchilada sauce
  • 1/2 cup heavy cream
  • 2 ounces softened cream cheese cubed
  • 2 1/2 cups shredded turkey
  • 8 ounces grated Monterey jack cheese
  • 6 ounces grated cheddar cheese
  • 2 cups red enchilada sauce
  • 10 Mission Foods flour tortillas
  • Toppings: sliced avocado sour cream, chopped cilantro


  • Preheat your oven to 400 degrees F.
  • In a medium bowl, toss the squash a tablespoon or two of olive oil and a dash of salt and black pepper. Pour the mixture onto a large baking sheet that has been lined with foil. Place it in the oven and roast the squash for about 40 minutes, or until tender. Remove from heat and set aside to cool slightly. Reduce the heat to 350 degrees F.
  • To a large skillet, add 2 tablespoons of olive oil. Heat over medium heat and add the onion. Cook until tender, about 5 minutes. Add the green chilies, chili powder, cumin and garlic powder. Cook for about 3 minutes or until the spices are fragrant. Stir in the green enchilada sauce and heavy cream. Bring to a gentle simmer and then stir in the cream cheese. Stir until the cheese has completely melted. Remove from heat and fold in the turkey and butternut squash. Take about half of the Monterey jack and cheddar cheese, and fold them in as well.
  • In a large baking dish, add about 1 cup of the red enchilada sauce. Spoon a small amount of the turkey mixture into each flour tortilla and roll up. Place them seam side down in the baking dish. Pour the remaining 1 cup of red enchilada sauce on top and any remaining filling. Top with remaining cheeses and place in the oven.
  • Bake the enchiladas for about 30 minutes or until melty. Remove from heat and top with desired toppings such as avocado, sour cream and cilantro. Enjoy!

I’m required to disclose a sponsored partnership between our site and Mission Foods. I have been compensated in exchange for this post in the form of payment, product or experiences.


Put those Thanksgiving leftovers to creative use! Make these Leftover Thanksgiving Turkey and Butternut Squash Enchiladas!

You may also like:



I’m the voice, author, creator, and photographer behind Cooking and Beer. We started things about 10 years ago and Cooking and Beer has morphed and grown into what it is today: providing hundreds of recipes to thousands of people.

13 Responses

  1. This is seriously amazing!! I love all the cheese and would have never thought of using flour tortillas for Thanksgiving leftovers. Brilliant idea!

Leave a Reply

Your email address will not be published. Required fields are marked *

Recipe Rating

Hello! I'm Justine.

I’m a blogger and web developer from the beautiful state of Oklahoma, where my loving husband, two adorable kids, and two mischievous dogs keep me on my toes 24/7. My idea of heaven includes endless summer days, getting lost in a good book, and whipping up some delicious homemade bread.


subscribe for email updates

subscribe for email updates

Join our fun and engaging community on Instagram! Follow us for the latest updates, events, and promotions, and connect with us through comments, likes, or DMs. Follow us now!

Subscribe to our newsletter for a variety of delicious recipes that will tantalize your taste buds. Join our community today and stay up-to-date with the latest and greatest recipes. Sign up now!

Need help updating your brand & website? Our expert team can provide tailored solutions to give you a competitive edge. Let’s chat!